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Dr. Sourav Banerjee
Scientist-IV / Associate Professor
  Email : sourav[AT]nbrc[dot]ac[dot]in, sourav[dot]nbrc[AT]gov[dot]in
 
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 Brain functions, ranging from simple reflexes to complex behavior, rely on the precise wiring of millions of neurons, or nerve cells. These neurons communicate with each other through synapses, which are highly specialized structures that mediate the transmission of information from one nerve cell to another. Synapses are established during development, as well as in the adult brain, and are remarkably plastic, undergoing constant remodeling (or synaptic plasticity) in response to experiences while communicating with the outside world. Dysfunction of neuronal circuits leads to numerous nervous system disorders including mental retardation, schizophrenia and autism spectrum disorders. To understand how the dysfunction of neuronal circuit contributes to the wide spectrum of nervous system disorders, it is important to perceive how synapses are formed, maintained, and function in a non-pathological setting. Towards this fundamental problem of neuroscience, our laboratory investigates novel epigenetic mechanisms involving non-coding RNAs and the Ubiquitin Proteasome System that fine-tune synapse development and synaptic plasticity.

 

We employ a wide range of biochemical, cell biological, and whole-cell patch clamp recording and use neurons from rat or mouse brain in primary culture or in vivo to address the following topics.

 

  • Molecular control of synapse formation by non-coding RNAs and the Ubiquitin Proteasome System
  • microRNA-mediated regulation of synaptic plasticity

  • From Stem Cell to Behaviour: Role of microRNA –mediated gene expression system in adult neural stem cells and its implication in development and function of feeding circuitry

Selected Publications:

Kumari, A., Balakumar, S., and Banerjee, S. (2017) Modulation of hippocampal synapse maturation by activity-regulated E3 ligase via non-canonical pathway. Neuroscience, in press.

Jammalamadaka, A., Banerjee, S., Kosik, K.S., and Manjunath, B.S. (2013). Statistical analysis of dendritic spine distributions in rat hippocampal cultures. BMC Bioinformatics, 2, 14(1):287

Lee, E. J*., BanerjeeS*., Zhou, H*., Jammalamadaka, A., Arcila, M., Manjunath, B.S., and Kosik, K.S. (2011). Identification of piRNAs in the central nervous system. RNA, 17, 1090-9. (Highlighted on Cover Page)*Equal Contribution

Shi, Y., Zhao, X., Hsieh, J., Wichterle, H., Impey, S., Banerjee, S., Neveu, P., and Kosik, K. S. (2010) microRNA regulation of neural stem cells and neurogenesis. Journal of Neuroscience30, 14931-14936.

Banerjee, S., Neveu, P., and Kosik, K. S. (2009) A coordinated local translation control point at the synapse involving relief from silencing and MOV10 degradation. Neuron, 64, 871-884. (Highlighted Article. Commentaries in BBC, Faculty of 1000 Biology and Science Daily).

 Position Available

Ph.D and Integrated Ph.D applicant - Please visit http://www.nbrc.ac.in/phd_neuroscience.php

NBRC accepts summer intern through Indian Academy of Science. Please apply directly to IAS and indicate your lab choice.

JRF position available for  NET qualified candidate. Please visit http://www.nbrc.ac.in/admin/careers/nb207.pdf

Collaborators

Ted Abel, University of Pennsylvania, USA

Dan Ohtan Wang, Institute for Integrated Cell-Material Sciences, Kyoto University, Japan

Sharba Bandyopadhyay, IIT Kharagpur

Dasradhi Palakodeti, inStem, Bangalore

Research Funding

  • Ÿ Ramalingaswami Fellowship, DBT
  • RNAi Grant, DBT
  • Genome Engineering Grant, DBT
  • National Brain Research Core Fund
  • Global Exchange Fund, University of Pennsylvania, USA
 
 
 
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