ABOUT
Like a geographical map, a brain template provides a standard reference coordinate system for brain structure analysis. NeuroImaging and NeuroSpectroscopy Laboratory at National Brain Research Centre (NBRC) have
constructed the first high resolution Indian population specific brain template, “BRAHMA”.
A dataset of high-resolution 3D T1, T2, and FLAIR images acquired from a group of 113 volunteers (M/F - 56/57, mean age 28.96 ± 7.80 years) are used to construct T1, T2, and FLAIR templates, collectively referred to as
“BRAHMA”. A processing pipeline is developed and implemented in a MATLAB based toolbox for template construction and generation of tissue probability maps and segmentation atlases, with additional labels for deep brain
regions such as the Substantia Nigra generated from the T2 and FLAIR templates. The use of BRAHMA template for analysis of structural and functional neuroimaging data from Indian participants provides improved accuracy
with statistically significant results over that obtained using the ICBM-152 (International Consortium for Brain Mapping) template.
The availability of different image contrasts, tissue maps, and segmentation atlases make the BRAHMA template a comprehensive tool for multimodal image analysis in laboratory and clinical settings.
GALLERY
Image 1: An overview of adult brain templates available for use from differentneuroimaging studies. The horizontal dotted lines drawn to the ICBM-152 template indicate the variation in height and length of the templates
Image 2: A comparison of global brain features of the BRAHMA template with existing templates (MNI-305, ICBM-152, ICBM-452, CBA-56, and SCBT-2020)
Image 3: The T1, T2, and FLAIR brain templates constructed for the Indian population from 113 individual scans. The axial slice (80 of 160), coronal slice (120 of 240), and sagittal slice (125 of 240) of the template images are shown
Image 4: A representation of comparative analysis of fMRI activations for the Sternberg Working Memory and Finger Tapping paradigms obtained with SPM12 using ICBM-152 and BRAHMA templates. The activation maps for the group-level analysis on the subjects are shown overlaid on T1-weighted images normalized using the respective templates.
PRE-REQUISITES
These are some of the primary prerequisites that are needed to run BRAHMA toolbox smoothly.
Ubuntu 16.04 and above
Matlab or Matlab Runtime Environment
Apart from these we require a few more toolboxes for operating the BRAHMA toolbox.
ATRA
MIPAV
ITK-SNAP
AFNI
Freesurfer
ANTS
FSL
ROBEX
Now it should work perfectly !
REFERENCES
DOWNLOAD
To download the BRAHMA toolbox please drop us a message along with the name of your organization on the Email ID mentioned below and we will send over a copy to you. To download the BRAHMA template from NeuroVault repository click the icon below.
EMAIL ID: pravat[dot]mandal[at]gmail[dot]com
TEAM MEMBERS
We made it happen........
Dr. Pravat K Mandal
Principal Investigator, NINS Lab, NBRC, India
Dr. Praful.P Pai
Research Scientist, NINS Lab, NBRC, India
Khushboo Punjabi
Research Scholar, NINS Lab,
NBRC, India
Dr. Deepika Shukla
Scientist, NINS Lab,
NBRC, India
Anshika Goel
Senior R & D Engineer, NINS Lab,
NBRC, India
Shallu Joon
Neuropsycologist, NINS Lab,
NBRC, India
Saurav Roy
R & D Engineer, NINS Lab,
NBRC, India
Kanika Sandal
R & D Engineer I, NINS Lab,
NBRC, India
Ritwick Mishra
Clinical Coordinator, NINS Lab,
NBRC, India
Ritu Lahoti
R & D Engineer, NINS Lab,
NBRC, India
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CONTACT US
Come and Meet us. We love to meet people who are into BRAIN's as much as we are.
Email ID : pravat[dot]mandal[at]gmail[dot]com
Location : NeuroImaging and NeuroSpectroscopy Lab, National Brain Research Centre, Near NSG Campus, NH-8, Manesar, Gurugram, Haryana–122051, India.
Neuroimaging and Neurospectroscopy Lab, National Brain Research Centre, Manesar, India
Created and Developed by Saurav Roy, Research and Development Engineer, Neuroimaging and Neurospectroscopy Lab, National Brain Research Centre, India