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NBRC has a modern animal facility to meet the requirements of the scientists for advanced neuroscience research. The Animal Facility procures and breeds a wide variety of species of laboratory animals and supplies quality animals to in-house researchers, which are used as animal models for understanding the human brain in health and disease. The Institute recognizes that the use of laboratory animals in research is an important privilege, which should be accompanied with a great ethical responsibility to ensure the humane care and use of these valuable subjects. To ensure appropriate care and use, detailed programs of excellent veterinary and husbandry care, and programs for the peer-reviewed evaluation of all protocols prior to the use of any animal in research are in place. NBRC is committed to the highest standards of research and recognizes that laboratory animals must receive the best possible care, not only to obtain valid research data, but also to ensure the health and safety of animals, researchers, and animal caretakers. The Animal Facility is registered with the Committee for the Purpose of Control and Supervision of Experiments on Animals (CPCSEA), Ministry of Environment and Forests, Government of India, New Delhi. All activities of the Laboratory Animal Facility are carried out as per standard operating procedures (SOPs). The Animal Facility maintains records of day-to-day activities as well as breeding, maintenance and experimentation as per the statutory requirement of CPCSEA. Qualified and trained veterinarians oversee all the animal health concerns, and provide all necessary veterinary care to ensure that healthy animals are available for research. The staff of the animal facility ensures humane and appropriate animal care.
All the animal species are housed in species-appropriate cages, which are designed as per the CPCSEA guidelines or exceed them. The outdoor play area for non-human primates has six large interconnected enclosures that provide a flexible layout for optimising enrichment and social interactions. The transgenic, knockout and mutant mice are housed under germ-free conditions in filter top cages and individually ventilated cages (IVC). Such animals are handled in laminar hoods, and the moved to fresh cages in the cage-changing station under hepa-filtered air. Close circuit monitoring cameras have been installed at various locations in the facility to help in effective monitoring of the animal facility.
All the animal species are housed in species-appropriate cages, which are designed as per the CPCSEA guidelines or exceed them. The outdoor play area for non-human primates has six large interconnected enclosures that provide a flexible layout for optimising enrichment and social interactions. The transgenic, knockout and mutant mice are housed under germ-free conditions in filter top cages and individually ventilated cages (IVC). Such animals are handled in laminar hoods, and the moved to fresh cages in the cage-changing station under hepa-filtered air. Close circuit monitoring cameras have been installed at various locations in the facility to help in effective monitoring of the animal facility.
The animal facility has a state-of-art surgical suite equipped with intensity controlled surgical lights, advanced surgical microscopes, gas anesthesia machines, equipment for monitoring the physiological state of the animals, including heart rate monitor, pulse-oximeter and rectal thermometer. For cleaning and sterilization of the surgical instruments there is an ultrasonic instrument cleaner, autoclave, glass bead steriliser and ethylene oxide gas steriliser. The animal facility has a necropsy room, perfusion room with a perfusion hood, deep freezer for carcass storage, and incinerator for disposal of the animal carcass.
The Veterinary staff of the Animal Facility also conducts a training course for Integrated M.Sc.-PhD and PhD students, and Project Assistants on laboratory animal science, principles of three R's, ethics, laws and guidelines on the regulation of scientific experiments on animals, general biology and reproduction of the laboratory animals, animal identification techniques, husbandry and care, sex differentiation, handling and restraint, and approved techniques for blood collection, injections, anesthesia and monitoring, humane euthanasia, etc
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